Program

13:45 - 14:00

Welcome Ceremony

14:00 - 16:00

Afternoon session

Chair: Irene Russo Krauss

14:00 - 14:30

Plenary Lecture

Luigi Messori 

"Protein Metalation by Metal-based Anticancer Drugs: the Concept, the State of the Art, the Prospects"

14:30 - 14:50

Alice Brink 

"Multinuclear metal complexes in proteins – interaction trends for the naturally unnatural"

14:50 - 15:10

Franc Perdih 

"Structural aspects of zinc and vanadium complexes with picolinato derivatives"

15:10 - 15:30

Tiziana Marino 

"Computational Studies into some Metalloproteins"

15:30 - 15:50

Andrea Pica 

"Accelerating Drug Discovery: ALPX Advanced Automated Crystallography and Cutting-Edge Screening Pipelines"

15:50 - 16:00

Short Presentation

Lidia Ciccone 

"Structural characterization of human serum prealbumin in complex with cisplatin and carboplatin"

Coffee Break and Poster Session 16:00 - 17:00

9:15 - 12:45

Morning session

Chair: Eugenio Garribba

9:15 - 9:45

Plenary Lecture

Debbie C. Crans 

"Development and application of vanadium complexes for treatment of diabetes and  cancer: specific phosphatase inhibitors and other active antiproliferative complexes"

9:45 - 10:05

Marco Chino

"Metal Center Substitution in a Minimalist Tetrathiolate Protein Scaffold"

10:05 - 10:25

Iogann Tolbatov 

"Taming the challenge of metal coordination modeling: novel computational strategies for description of protein metalation by uranyl and lead"

10:25 - 10:45

Pratikshya Das Pattanayak 

"Theranostic Potential of Nonoxido V(IV): Lysosome-Targeted Anticancer Metallodrugs"

Coffee break 10:45 - 11:15

11:15 - 11:35

Tiziano Marzo 

"An outlook on pharmaceutical inorganic compounds for cancer: from mechanistic aspects to emerging opportunities"

11:35 - 11:55

Timm Schreiber 

"Insoluble HIFa protein aggregates by cadmium disrupt hypoxia-prolyl hydroxylase (PHD)-hypoxia inducible factor (HIFa) signaling in renal epithelial (NRK-52E) and interstitial (FAIK3-5) cells"

11:55 - 12:15

Konrad Kowalski 

"Biferrocenyl ferroptosis inducer in lung cancer cells"

12:15 - 12:35

Pavel Štarha 

"Interaction of Small Biomolecules with Anticancer Rh(III) and Ir(III) Half-sandwich Complexes Involving Metal-activated Ligands"

12:35 - 12:45

Short Presentation

Lara Massai 

"Metals in medicine: ESI-MS analysis of protein targets in diverse diseases"

Lunch 12:45 - 14:00

14:00 - 16:00

Afternoon session

Chair: Daniela Marasco

14:00 - 14:30

Plenary Lecture

Annette Rompel

"Polyoxometalate as superchaotropic transmembrane carriers"

14:30 - 14:50

Wolfgang Weigand 

"[FeFe]-Hydrogenase Mimics for Photocatalytic Hydrogen Evolution Reactions"

14:50 - 15:10

Adoración Gómez Quiroga

"The development of effective new metallodrugs with targets beyond DNA. The importance of sample preparation in their mechanism of action"

15:10 - 15:30

Sankar Chandra Moi 

"Role of BSA protein-Pt(II) complex interaction for anticancer drug design and drug development: their DNA binding, anticancer activity, cell cycle arrest and molecular docking"

15:30 - 15:50

Azzurra Stefanucci

"Development of linear β-turn inducers containing peptides as arc mimetics with DNA topological and sequence selectivity"

15:50 - 16:00

Short Presentation

Romualdo Troisi

"Gold binding and unique protein conformation in the adduct formed upon reaction of aurothiomalate with apo-transferrin"

Coffee Break and Poster Session 16:00 - 17:00

9:15 - 12:45

Morning session

Chair: Giarita Ferraro

9:15 - 9:45

Plenary Lecture

Santiago Herrero Domínguez 

"Challenges and opportunities in diruthenium metalloproteins"

9:45 - 10:05

Alessia Ruggiero 

"Biophysical characterizations provide insights into calcium and phosphate binding by human annexin A4"

10:05 - 10:25

Bohdan Adler 

"Homocysteine interaction with physiological metals"

10:25 - 10:45

Andrea Ilari 

"Targeting the Trypanothione Pathway through Protein Metalation"

Coffee break 10:45 - 11:15

11:15 - 11:35

Saverio Santi 

"Modulation of Redox potential in Fc-peptides with potential antitumor activity"

11:35 - 11:55

Irvin Noel Booysen 

"Anti-amyloid aggregation and anti-hyperglycemic activities of ruthenium uracil Schiff base compounds and their chitosan-polyvinyl alcohol electrospun nanofiber conjugates"

11:55 - 12:15

Jean-Didier Pierre Maréchal

"Molecular Modeling for Uncovering Protein Metalation Mechanisms "

12:15 - 12:35

Jürgen Gailer 

"LC-ICP-AES: a powerful tool to probe the metalation/de-metalation of peptides/proteins"

12:35 - 12:45

Short Presentation

Gianluca D'Abrosca

"Ros/MucRfamily members mediate DNA condensation in a-proteobacteria by circular oligomeric particles"

12:45 - 13:00

Award Ceremony